Amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis, which is known as motor neuron disease, motor neuron disease. It is a progressive neurodegenerative disease in which motor neurons in the brain and spinal cord gradually die, making it impossible to control the muscle brain and then the muscles contract due to lack of exercise. The patient will completely lose mobility in the later stages of the disease and may eventually die due to inability to breathe.
The cause of amyotrophic lateral sclerosis
In most patients, the hereditary, adult type is autosomal dominant, young type is autosomal dominant or recessive, and clinically difficult to distinguish from sporadic cases. Modern genetic studies have determined that autosomal dominant genotypes are associated with mutations in the copper / zinc superoxide dismutase (SODL) gene.
Secretion of brain-derived neurotrophic factor
Abnormal secretion of neurotrophic factor can affect motor neurons, when glial cells around motor neurons mutate, they can contribute to the formation of nitric oxide and hydrogen peroxide, thereby causing apoptosis or death of motor neurons. Both of them can lead to lateral sclerosis of amyotrophy.
The factor of poisoning
Lead can destroy upper and lower motor neurons, and lead content in water and soil in some areas with high amyotrophic lateral sclerosis is higher than in other regions. In addition to damage to motor neurons, lead and other metals, sensory nerves are damaged.
Conventional treatment of amyotrophic lateral sclerosis
Currently, there are no drugs that will cure the disease, patients require maintenance therapy to relieve symptoms.
Symptomatic treatment, proper exercise. For example, pay attention to the function of the respiratory and digestive tract, if there is more saliva, a small amount of antialkamine can be given, and if more, it can be caused by spray and sputum, if there is depression and antidepressant.
Currently internationally recognized and the only drug approved by the U.S. Food and drug administration (FDA) for the treatment of amyotrophic lateral sclerosis is Rilutek, which helps restore muscle strength.
If breathing is not smooth, you can use regular oxygen or use a double positive pressure fan (BiBAP) to help your breathing. When further respiratory failure occurs, you need a tracheotomy and use a respirator.
Stem cells in the treatment of amyotrophic lateral sclerosis
Currently, there is no effective treatment for amyotrophic lateral sclerosis, but scientists are always in the process of finding an effective treatment . With the further development of stem cell potential and regenerative medicine, stem cell therapy is expected to be an effective relief for patients.
Stem cells repair the brain and spinal cord and reduce inflammation of the brain
Neonatal motor neural cells restore functional integrity of neural pathways
Acts of inflammatory cells, promotes endogenous recovery, promotes the secretion of neurotrophic factors, improves survival and slows the progression of the disease